Methyl pyrimidin-2-yl sulphone
2-METHANESULFONYL-PYRIMIDINE
CAS: 14161-09-2
Molecular Formula: C5H6N2O2S
Methyl pyrimidin-2-yl sulphone - Names and Identifiers
| Name | 2-METHANESULFONYL-PYRIMIDINE |
| Synonyms | 2-METHANESULFONYL-PYRIMIDINE 2-(Methylsulfonyl)pyrimidine Methyl pyrimidin-2-yl sulphone |
| CAS | 14161-09-2 |
Methyl pyrimidin-2-yl sulphone - Physico-chemical Properties
| Molecular Formula | C5H6N2O2S |
| Molar Mass | 158.18 |
| Storage Condition | Room Temprature |
Methyl pyrimidin-2-yl sulphone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
Methyl pyrimidin-2-yl sulphone - Upstream Downstream Industry
Methyl pyrimidin-2-yl sulphone - Uses and synthesis methods
application
2-Methyl pyrimidine can be used as an intermediate in pharmaceutical synthesis and an intermediate in organic synthesis, mainly used in laboratory research and development processes and chemical pharmaceutical synthesis processes.
Preparation
The specific steps for the preparation of 2-thionopyrimidine are as follows: The suspension of potassium carbonate (27.6g,0.2mol) in acetone (200ml) solution of 2-mercaptopyrimidine (0.1mol) and methyl iodide (18.7ml,0.3mol) is heated and refluxed for 3 hours. The reaction mixture is allowed to cool, then filtered, and then evaporated in vacuum. The mixture was distilled at a pressure of 0.01mmHg to give 12.7g of 2-methylthio -4, 6-dimethylpyrimidine, a white solid. A portion of this solid (4.42g,28.7mmol) was dissolved in dichloromethane (200ml) and m-chloroperoxybenzoic acid (50%,22.8g,66.0mmol) was added in batches. The resulting mixture is stirred for 5 days, finally filtered, and then evaporated in vacuum. Purified by silica gel rapid column chromatography with ether as eluent, 2-methylsulfonyl pyrimidine was obtained as a white solid, m.pt.,81 ℃.
Last Update：2024-04-09 21:21:28
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Raw Materials for Methyl pyrimidin-2-yl sulphone